Cross-sectional and longitudinal estimates of atrophy rates were similar. We found significant decreases in cross-sectional whole-brain (P<.001), temporal lobe (P<.001), and hippocampal (P =.003) volumes and a significant increase in ventricular volume (P<.001) with increasing age. Measurements included the whole-brain, temporal lobe, hippocampal, and ventricular volumes at baseline and for repeat scans. Thirty-nine healthy control subjects (age range, 31-84 years) underwent serial magnetic resonance imaging assessments. To investigate the effect of age on global and regional brain volumes and rates of atrophy, and to compare directly results based on cross-sectional and longitudinal data.
0 kommentar(er)
